Cochrane News

Cochrane is a British non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers. Cochrane contributors (37,000 from more than 130 countries) work together to produce credible, accessible health information that is free from commercial sponsorship and other conflicts of interest. Many of our contributors are world leaders in their fields – medicine, health policy, research methodology, or consumer advocacy – and our groups are situated in some of the world’s most respected academic and medical institutions. Contact us for more information.


Immersion in water in labour and birth

What is the issue? To assess the effects of water immersion (waterbirth) during labour and/or birth (first, second and third stage of labour) on women and their infants. Why is this important? Many women choose to labour and give birth in water (water immersion) and this practice is becoming more […]


Epidural with intermittent (automated mandatory bolus) versus constant delivery (basal infusion) for maintaining pain relief in childbirth

We included 12 studies with a total of 1121 women. Ten studies enrolled healthy nulliparous women only and two studies enrolled healthy parous women at term as well. All studies excluded women with complicated pregnancies. There were variations in the technique of initiation of epidural analgesia. Seven studies utilized the […]


Trihexyphenidyl for dystonia in cerebral palsy

Review question Is trihexyphenidyl a helpful treatment for people with cerebral palsy who have a movement problem called dystonia? Background Cerebral palsy is a common condition that covers a range of movement problems. One common movement problem is dystonia, which makes it difficult for people with cerebral palsy to control […]


L-ornithine L-aspartate for people with chronic liver disease and hepatic encephalopathy (poor brain functioning)

Background Cirrhosis is a chronic disorder of the liver. People with this condition commonly develop hepatic encephalopathy, a complication that results in poor brain functioning. Some people with cirrhosis develop obvious clinical features of disturbed brain functioning, such as difficulties with speech, balance and daily functioning; they are said to […]


The Cochrane Library App

The Cochrane Library App presents the latest up-to-date evidence from the Cochrane Library in a convenient, easy to navigate format which provides you with relevant, accessible research, when you need it, from the world’s leading experts in evidence-informed health care. All content in the app is free, and new issues […]


Role of inhaled corticosteroids (ICS) in the management of bronchiectasis

Background Bronchiectasis is a lung disease. People with bronchiectasis often experience long-term symptoms such as productive or wet cough, repeated flare-ups (exacerbations) and poor quality of life. People with bronchiectasis have airway inflammation and many have asthma-like symptoms (such as cough and wheeze). Because of this, inhaled corticosteroids (ICS), commonly […]


Cochrane seeks Product Manager – London, UK

Specifications: Full TimeSalary: CompetitiveLocation: London, UKApplication Closing Date: 25 may 2018 This role is an exciting opportunity to use your experience in Product Management to make a difference in the field of health care research.   The Product Manager will own the Cochrane Library as a product through its lifecycle […]


Immersion in water during labour and birth

Abstract Background Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal […]


Dying Matters Awareness Week

14 – 20 May 2018 is Dying Matters Awareness Week. Every year in May, Dying Matters and its coalition members host an Awareness Week, which gives an opportunity to place the importance of talking about dying, death and bereavement firmly on the national agenda. The theme for 2018 is, “What […]


Optimized anaesthesia depth guided by brain electrical activity for protection against postoperative delirium and cognitive dysfunction in adults

Review question We wanted to discover whether using brain electrical activity monitoring to guide doses of anaesthetics can reduce the risk of postoperative delirium (POD) and cognitive dysfunction (POCD) in adults undergoing general anaesthesia for non-cardiac and non-neurological surgical procedures. Background Postoperative delirium (POD) is a disturbed state of mind […]


Antidepressants for insomnia

Why is this review important? Insomnia (having difficulty falling or staying asleep) is common, approximately one in five people report sleep problems in the preceeding year. Insomnia can cause daytime fatigue, distress, impairment of daytime functioning and reduced quality of life. It is associated with increased mental health problems, drug […]


Are psychological therapies effective in treating depression that did not get better with previous treatment?

We included six trials (n = 698; most participants were women approximately 40 years of age). All studies evaluated psychotherapy plus usual care (with antidepressants) versus usual care (with antidepressants). Three studies addressed the addition of cognitive-behavioural therapy (CBT) to usual care (n = 522), and one each evaluated intensive […]


Glucocorticosteroids administered after Kasai surgical procedure for infants with blocked or damaged bile duct

Medications used postoperatively (immediately after surgery) for infants with blocked or damaged bile duct (that is, biliary atresia) Review questionDo medications, called glucocorticosteroids (steroids), have beneficial or harmful effects in the health of infants with biliary atresia operated by the Kasai surgical procedure (that is, portoenterostomy)? We reviewed if there […]