Cochrane

Cochrane is a British non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers. Cochrane contributors (37,000 from more than 130 countries) work together to produce credible, accessible health information that is free from commercial sponsorship and other conflicts of interest. Many of our contributors are world leaders in their fields – medicine, health policy, research methodology, or consumer advocacy – and our groups are situated in some of the world’s most respected academic and medical institutions. Contact us for more information.


Cooling plus inhaled xenon for newborns with hypoxic-ischaemic encephalopathy

Authors’ conclusions:  Current evidence from one small randomised controlled pilot trial is inadequate to show whether cooling plus xenon is safe or effective in near-term and term newborns with HIE. Further trials reporting long-term neurodevelopmental outcomes are needed. Read the full abstract… Data collection and analysis:  Two review authors independently […]


Client feedback in psychological therapy for children and adolescents with mental health problems

Why is this review important? Systematic feedback from clients to psychotherapists may improve outcomes of psychological therapy. Typically, client feedback is provided regularly throughout the course of therapy. Clients fill in a questionnaire about how they feel about the therapy and how they are feeling in general. The questionnaire is […]


E-health interventions for anxiety and depression in children and adolescents with long-term physical conditions

Why is this review important? More than one in ten children and adolescents worldwide have long-term physical conditions, such as asthma, diabetes, and cancer. They are more likely to develop psychological problems, which include anxiety or depression. Treating such problems early can prevent difficulties with friendships, family life, school, and […]


Mindfulness-based stress reduction for family carers of people with dementia

We included five RCTs involving 201 carers assessing the effectiveness of MBSR. Controls used in included studies varied in structure and content. Mindfulness-based stress reduction programmes were compared with either active controls (those matched for time and attention with MBSR, i.e. education, social support, or progressive muscle relaxation), or inactive […]


Transabdominal ultrasound and endoscopic ultrasound for detection of gallbladder polyps and differentiating between polyp types

BackgroundThe gallbladder is an organ situated close to the liver. It stores bile, produced by the liver, before it is released to the small bowel for digestion. Abnormal growths inside the gallbladder, called ‘gallbladder polyps‘, can develop. Most polyps (90%) are harmless; these are called pseudo polyps. The remaining are […]


Cochrane Infectious Diseases Group seeks Clinical Research Associate in Evidence Synthesis – Liverpool, UK

Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases. LSTM’s Centre for Evidence Synthesis in Global Health has led developments in systematic reviews in tropical medicine and […]


Treatments to improve pregnancy outcomes for women who develop diabetes during pregnancy: an overview of Cochrane systematic reviews

We included 14 reviews. Of these, 10 provided relevant high-quality and low-risk of bias data (AMSTAR and ROBIS) from 128 randomised controlled trials (RCTs), 27 comparisons, 17,984 women, 16,305 babies, and 1441 children. Evidence ranged from high- to very low-quality (GRADE). Only one effective intervention was found for treating women […]


Do interventions to enhance one-to-one support provided by partners, family members, or 'buddies' help smokers quit?

Background Smokers are more likely to quit when others in their social circle quit. They are also more likely to be successful when they receive active support to quit. Life partners, family members, friends, and others are all viable sources of support. This review investigated whether interventions designed to train […]